ACIC and GF’s experience with pharmaceutical filling of sterile and non-sterile products encompasses different glass and plastic packaging presentations such as ampoules, vials, syringes, cartridges, carpules, pots, tubes, IV bottles, and IV bags.

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OFM Series: Filling & Closing Machines for Pharmaceutical Processing

The OFM Series of filling and closing machines are specifically designed for filling, plugging, and capping both sterile and non-sterile products, such as syrup, ophthalmic solution, and nasal spray in either glass or plastic containers.

They combine the accessibility of linear machines and the compact design of the proven mono-bloc system.

The OFM Series have been developed to meet the current pharmaceutical industry standards and requirements with its compact design that reduces the space taken in the clean room or with other containment systems such as open or closed RABS.

They can also work with intermittent motion for low to medium production, or with continuous motion for high speed production.

  • Versatile and modular design to adapt to different containers and closure types to ensure high degree of flexibility over a wide range of products and applications
  • Optimized design and structure to allow easy cleaning for all working surfaces due to the absence of dead zones and corners
  • Possibility to adapt different dosing systems such as, rotary piston pumps, mass flow meters, time-pressure dosing, and peristaltic pumps
  • High filling accuracy
  • Simple orientation, quick change-overs, and low maintenance
  • All product contacting parts are made of AISI 316L stainless steel with finishing ranging from 0.4 – 0.8 RA, or with FDA approved materials
  • Low energy consumption with the ability to work for prolonged periods
  • Reduced start-up time
  • High production rate and line efficiency
  • Easy operator control
  • Compliant with 21 CFR part 11 FDA guideline
  • User friendly touch screen operator interface (HMI)
  • Production capacity from 30 – 600 containers/minute
  • Customized layout in accordance to special end-user demands
  • Inline connection to upstream and downstream equipment
  • Container feeding from unscrambling unites, rotary or bi-flow tables, depending on the process and layout configuration
  • Container air blowing station by means of sterile or ionized air for particle removal
  • Intermediate tank with level controller using weighing cells
  • Statistical or 100% IPC
  • Nitrogen purging before, during, and after the filling operation
  • Descaled and passivated filling circuit
  • Pressure and torque automatic control
  • Closure presence control and automatic rejection systems
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation
  • Printer and SCADA interface for production data recording and management

BFM Series: Filling & Closing Machines for Bottles

The BFM Series of filling and closing machines are suitable for high speed processing of PE and PP bottles.

They combine the accessibility of linear machines and the compact design of the proven mono-bloc systems.

The BFM Series can also accommodate multiple closing stations, for Euro-caps or standard screw caps (irrigation bottles).

  • Optimized design and structure to allow easy cleaning for all working surfaces due to the absence of dead zones and corners
  • All product contacting parts are made of AISI 316L stainless steel with finishing ranging from 0.4 – 0.8 RA, or with FDA approved materials
  • Easy operator control
  • Ability to accommodate multiple closing stations for Euro-caps or standard screw caps (irrigations bottles)
  • Accurate filling system (using time-pressure)
  • Simple orientation, quick change-overs, and low maintenance
  • Compliant with 21 CFR part 11 FDA guideline
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance to special end-user demands
  • Continuous container transport
  • Remote assistance
  • Printer and SCADA interface for production data recording and management
  • Integration with convectional LAF or RABS
  • Documentation packages for complete system validation

AFM Series: Filling & Sealing Machines for Ampoules

The AFM Series of filling and closing machines are designed to process both closed and open ampoules.

They are suitable for both liquid parenterals and products that must undergo lypholisation process.

The AFM Series have been developed to meet the current pharmaceutical industry standards and requirements with its compact design that reduces the space taken in the clean room or with other containment systems such as, RABS or isolators.

They can also be integrated with conventional LAF Systems, RABS, or Isolators.

The COMBI version of the AFM Series are equipped with brushless motors for more versatility production, which is complemented with stoppering and sealing modules to treat alternatively both ampoules and vials with the same equipment.

  • Optimized design and structure to allow easy cleaning for all working surfaces due to the absence of dead zones and corners
  • Gas and Oxygen safety valves
  • Flame ignition control
  • Possibility to adapt different dosing systems such as, rotary piston pumps, mass flow meters, time-pressure dosing, and peristaltic pumps
  • High filling accuracy
  • Simple orientation, quick change-overs, and low maintenance
  • All product contacting parts are made of AISI 316L stainless steel with finishing ranging from 0.4 – 0.8 RA, or with FDA approved materials
  • Low energy consumption with the ability to work for prolonged periods
  • Reduced start-up time
  • High production rate and line efficiency
  • Easy operator control
  • Compliant with 21 CFR part 11 FDA guideline
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance to special end-user demands
  • Inline connection to upstream and downstream equipment
  • Possibility of wall installation configuration
  • Container feeding from unscrambling unites, rotary or bi-flow tables, depending on the process and layout configuration
  • Pre-heating treatment to process closed ampoules
  • Intermediate tank with level controller using weighing cells
  • Statistical or 100% IPC
  • Nitrogen purging before, during, and after the filling operation
  • Descaled and passivated filling circuit
  • Vials stoppering and sealing/crimping (COMBI version)
  • Closure presence control and automatic rejection systems
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation
  • Printer and SCADA interface for production data recording and management

SYFILL Series: Filling & Stoppering Machine for Nested Containers

The SYFILL Series of filling and stoppering machines have been specifically designed to process pre-sterilized nested containers such as, syringes and cartridges.

They have been developed to meet the current pharmaceutical industry standards and requirements with its compact design that reduces the space taken in the clean room.

The SYFILL Series can also be integrated with conventional LAF Systems, RABS, or Isolators.

  • Optimized design and structure to allow easy cleaning for all working surfaces due to the absence of dead zones and corners
  • Ability to work as a stand-alone unit or as a part of a complete processing line
  • Selective Compliance Assembly Robot Arm (SCARA) motion for precise movement and filling
  • Possibility to adapt different dosing systems such as, rotary piston pumps, mass flow meters, time-pressure dosing, and peristaltic pumps
  • All product contacting parts are made of AISI 316L stainless steel with finishing ranging from 0.4 – 0.8 RA, or with FDA approved materials
  • Compliant with 21 CFR part 11 FDA guideline
  • User friendly touch screen operator interface (HMI)
  • Formats ranging from 0.5 – 20 ml
  • Production capacity from 30 – 500 containers/minute
  • Simple operation, quick changeover, and low maintenance
  • Customized layout in accordance to the special end-user demands
  • Possibility of wall installation configuration
  • Manual or automatic de-bagging and de-lidding stations
  • Statistical or 100% IPC
  • Vacuum assisted filling and stoppering function for high viscosity and oxygen sensitive products
  • Container feeding from unscrambling unites, rotary or bi-flow tables, depending on the process and layout configuration
  • Possibility to equip filling system with rotary piston pumps, mass flow meters, time-pressure dosing, or peristaltic pumps
  • Closure presence control and automatic rejection systems
  • Descaled and passivated filling circuit
  • Nitrogen purging before, after, during, and after the filling operation
  • Intermediate tank with level controller using weighing cells
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation
  • Inline connection to upstream and downstream equipment
  • Printer and SCADA interface for production data recording and management

VFM Series: Filling & Closing Machines for Aseptic Processing

The VFM Series of filling and closing machines are designed for vial filling, stoppering, and sealing operations of injectable products in aseptic conditions.

They are suitable for both liquid parenterals and products that must undergo lypholisation process.

The VFM Series have been developed to meet the current pharmaceutical industry standards and requirements with its compact design that reduces the space taken in the clean room or with other containment systems such as, RABS or isolators.

They can also work with intermittent motion for low to medium production, or with continuous motion for high speed production.

  • Optimized design and structure to allow easy cleaning for all working surfaces due to the absence of dead zones and corners
  • Vial feeding from depyrogenation tunnel by means of rotary or by-flow tables
  • Possibility to adapt different dosing systems such as, rotary piston pumps, mass flow meters, time-pressure dosing, and peristaltic pumps
  • High filling accuracy
  • Simple orientation, quick change-overs, and low maintenance
  • All product contacting parts are made of AISI 316L stainless steel with finishing ranging from 0.4 – 0.8 RA, or with FDA approved materials
  • Low energy consumption with the ability to work for prolonged periods
  • Reduced start-up time
  • High production rate and line efficiency
  • Easy operator control
  • Compliant with 21 CFR part 11 FDA guideline
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance to special end-user demands
  • Inline connection to upstream and downstream equipment
  • Possibility of wall installation configuration
  • Container feeding from unscrambling unites, rotary or bi-flow tables, depending on the process and layout configuration
  • Vacuum stoppering for oxygen sensitive products
  • Intermediate tank with level controller using weighing cells
  • Half stopper application
  • Closure presence control and automatic rejection systems
  • Statistical or 100% IPC
  • Nitrogen purging before, after, during, and after the filling operation
  • Descaled and passivated filling circuit
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation
  • Printer and SCADA interface for production data recording and management

VFM Manipulator Series: Filling & Closing Machines for Flexible & Biotech Processing

The VFM Manipulator Series of filling and closing machines are designed for to endure a high degree of flexibility for special and biotech applications over a wide range of containers such as, vials, cartridges, and prefilled syringes either bulk or nested.

The robotic arms used have been specifically designed to be used for aseptic environments. They can be equipped with terminal gripping heads that allow a fully automated changeover from a dedicated tools magazine.

The VFM Manipulator Series have been developed to meet the current pharmaceutical industry standards and requirements with its compact design that reduces the space taken in the clean room or with other containment systems such as, RABS or isolators.

The VFM Manipulator Series can easily integrate in-line weighing systems and camera based quality controls.

The production capacity ranges based upon customer requirements.

  • Optimized design and structure to allow easy cleaning for all working surfaces due to the absence of dead zones and corners
  • Vial feeding from depyrogenation tunnel by means of rotary or by-flow tables
  • Possibility to adapt different dosing systems such as, rotary piston pumps, mass flow meters, time-pressure dosing, and peristaltic pumps
  • High filling accuracy
  • Fully automated changeover
  • Simple orientation, quick change-overs, and low maintenance
  • All product contacting parts are made of AISI 316L stainless steel with finishing ranging from 0.4 – 0.8 RA, or with FDA approved materials
  • Compliant with 21 CFR part 11 FDA guideline
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance to special end-user demands
  • Container air blowing station by means of sterile or ionized air for particle removal
  • Container feeding from unscrambling unites, rotary or bi-flow tables, depending on the process and layout configuration
  • Vacuum stoppering for oxygen sensitive products
  • Intermediate tank with level controller using weighing cells
  • Closure presence control and automatic rejection systems
  • Statistical or 100% IPC
  • Nitrogen purging before, after, during, and after the filling operation
  • Descaled and passivated filling circuit
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation
  • Printer and SCADA interface for production data recording and management

VCM Series: Closing & Sealing Machines for Bottles & Vials

The VCM Series of fully automatic closing/capping and sealing machines are designed for the application of different closures on glass and plastic vials and bottles.

They have been developed to meet the current pharmaceutical industry standards and requirements with its compact design that reduces the space taken by the machine.

The VCM Series can work with intermittent motion for low to medium production, or with continuous motion for high speed production.

  • Possibility of being equipped with a variety of different closing heads, either mechanical clutches or servo motors to handle: pressure caps (plugs, droppers, & dosing caps)
  • Possibility of providing different types of sealing system for aluminum sealing: conventional rotary heads, pressure rotary sealing heads against a fixed blade, independent blade rotary heads, & crimping heads for low particle generation (recommended for aseptic processing)
  • Compact design and footprint
  • Optimized design and structure to allow easy cleaning for all working surfaces due to the absence of dead zones and corners
  • Simple orientation, quick change-overs, and low maintenance
  • Low energy consumption with the ability to work for prolonged periods
  • High production rate and line efficiency
  • Easy operator control
  • Compliant with 21 CFR part 11 FDA guideline
  • User friendly touch screen operator interface (HMI)
  • Production capacity from 30 – 600 vials/minute
  • Customized layout in accordance to special end-user demands
  • Inline connection to upstream and downstream equipment
  • Container feeding from unscrambling unites, rotary or bi-flow tables, depending on the process and layout configuration
  • Integrated labeling unit
  • Pressure and torque automatic control
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation
  • Printer and SCADA interface for production data recording and management

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