As people are the greatest source of contamination during aseptic manufacturing of drugs, reducing personnel interventions into the process zone has significant impact on the quality of the final product.
From small to large batch production systems our proficiency extends to all fields that require particular attention to asepsis during filling processes for both non-toxic sterile and cytotoxic products which require totally enclosed environments.

Together ACIC Machinery and our partner, Tema Sinergie, develop custom-designed barrier systems for your manufacturing processes.

Specific equipment can be also supplied along with the barrier system, such as Isolator Systems, Active Bio-decontamination Pass Through Chambers, and Sterility Testing Isolators to perform all the process steps.

Our equipment is designed to meet all existing requirements for aseptic processing. RABS provide protection by delivering a physical and aerodynamic barrier over a critical process zone with easier access to the process in the event a human intervention is required.

We develop different kinds of RABS:

  • Open Passive RABS: barrier system which utilizes existing cleanroom overhead air supply systems to deliver HEPA filtered air over a critical process before returning air back into the clean room.
  • Open Active RABS: barrier system which has an integrated ventilation system to supply HEPA filtered air over a critical process before returning air back into the clean room.
  • Closed RABS: a positive pressure system which has an integrated ventilation system to supply HEPA filtered air over a critical process, which can pass through return filters before being recirculated. Closed RABS can also be integrated with a bio-decontamination system to provide a cGMP class A/ISO 5 environment.