Overview: Sterilization & Packaging Line for RTU Containers

Together with our partner PBL, ACIC Machinery custom designed, built and successfully commissioned a complete line for Ready-to-Use (RTU) containers.

  • The line consists of three stations: washing machine, depyrogenation tunnel, and tray loading system, fully integrated for maximum productivity.
  • No glass-to-glass contact protects containers from cosmetic defects, particles and contamination.
  • Each production process uses state-of-the-art equipment.
  • Certified ISO 7 and ISO 5 using validated processes that are constantly monitored and controlled.
  • Production output: 100 to 400 BpM

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  • Custom robotic loading and unloading system
  • Complete washing and drying cycle – independent stations minimize utility consumption
  • Internal siliconization cycle
  • Robotic Loading/Unloading
  • Compact wet chamber
  • Fast change format
  • Siliconization cycle
  • Different monitoring functions
  • Customized transportation chain
  • User-friendly and fast tool-free format change
  • Designed as a modular machine
Picture of washing machine for RTU syringes

Depyrogenation Tunnel

  • Depyrogenation tunnel with 6 Log reduction
  • custom container transport system with automatic recirculation
  • Depyrogenation tunnel
  • Inlet chamber
  • Hot chamber
  • Cooling chamber
  • 6 Log reduction
  • User-friendly and fast tool-free format change
  • Designed as a modular machine
Depyrogenation tunnel for ready-to-use containers


  • Different type of closures available (RNS, NS, TC, OVS)
  • Nesting and tub insertion
  • Tray loading – consumables warehouse with high capacity storage
  • Tyvek positioning with final sealing and sterile bagging – high precision with all steps monitored
  • Capping/alu process
  • Siliconization process
  • Control of stopper/alu position
  • Control of correct silicon application
  • Syringes and Cartridge TUB and NEST preparation
  • Vial trays
  • Container nesting
  • Control of complete and conforming nest
  • Tyvek position and sealing
  • Sterile bagging
Automatic packaging machine for RTU syringes into tub

Main Container Types: Nested Syringes, Vials and Cartridges

RTU Containers