Products

Filling and closing

ACIC Machinery is a leading provider of filling and sealing solutions ranging from small and large volume parenteral products to sterile and non-sterile filling, plugging, and capping of products such as vaccines, ophthalmic solutions, syrup, and nasal spray in either glass or plastic containers. Applications include ampoules, vials, syringes (single and multi-chamber syringes), cartridges, glass/plastic bottles, soft bags, and custom container types. These machines can process liquid, semi-solid, and powder products.

a collection of ampules

Product Lines

Blood Bag Forming Machines

Vial Filling and Closing

Click for syringe filling

Syringe Filling and Closing

Click for cartridge filling

Cartridge Filling and Closing

Click for microdose

Microdose Filling and Closing

click for bottle filling

Bottle Filling and Closing

click for nested syringes, Cartridges, and Vials

Nested Syringes, Cartridges, and Vials

click for multiple containers

Multiple Containers

click for bag filling

Bag Filling

Vial Filling and Closing

Our vial filling and closing machines are custom designed for filling, stoppering, and sealing of vials for sterile applications including vaccines and injectable products. They are suitable for both liquid and lyophilized products.  

  • Compact footprint and custom designed layout based on end user requirements.
  • Versatile and modular design to adapt to different containers and closure types to ensure a high degree of flexibility over a wide range of products and applications.
  • High filling accuracy.
  • User friendly operator interface (HMI).
  • Parameter adjustments from HMI (filling volume, recipes, etc.).
  • Half stopper application or complete stopper application (dependent on product requirements).
  • Automatic unloading of vials onto trays or nest, or in-line connection with downstream equipment.
  • Low energy consumption with the ability to work for prolonged periods.
  • Easy cleaning of all working surfaces.
  • High production rate (10-400 vials/min) and line efficiency.

Our capping and sealing machines are designed for the application of various closures and seals on glass and plastic vials.

  • Possibility of being equipped with a variety of different closing heads, either mechanical clutches or servo motors to handle: pressure caps (plugs, droppers, & dosing caps)
  • Possibility of providing different types of sealing system for aluminum sealing: conventional rotary heads, pressure rotary sealing heads against a fixed blade, independent blade rotary heads, and crimping heads for low particle generation (recommended for aseptic processing)
  • Compact design and footprint
  • Optimized design and structure to allow easy cleaning for all working surfaces due to the absence of dead zones and corners
  • Simple orientation, quick change-overs, and low maintenance
  • Low energy consumption with the ability to work for prolonged periods
  • High production rate and line efficiency
  • Easy operator control
  • Compliant with 21 CFR part 11 FDA guideline
  • User friendly touch screen operator interface (HMI)
  • Production capacity from 30 – 600 vials/minute

  • Inline connection to upstream and downstream equipment
  • Container feeding from unscrambling units, rotary or bi-flow tables, depending on the process, and layout configuration
  • Vacuum stoppering for oxygen sensitive products
  • Intermediate tank with level controller using weighing cells
  • Half stopper application
  • Closure presence control and automatic rejection systems
  • Statistical or 100% IPC
  • Nitrogen purging before, after, during, and after the filling operation
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation
  • Inline connection with our automatic inspection systems for inspection of particulate matter, leak, or cosmetic defects.

Filling type is chosen based on product characteristics and end user requirements.

  • Rotary piston pumps (standard)
  • Peristaltic pumps
  • Mass flow meters
  • Time-pressure filling system
  • Custom dosing systems

Syringe Filling and Closing

Compact rotary filling machine for prefilled syringes (single or multi-chamber), bulk or nested. Automatic filling and closing of syringes, designed to be used in sterile environments.

Syringe filling and closing lines can be integrated with our packaging lines for automatic inline transfer to nesting, tubbing, or custom packaging stations (upon request).  

Automatic inspection systems can be integrated at every station for components presence inspection, particulate matter inspection, fill-level check, and cosmetic inspection.

  • Easy cleaning for all working surfaces
  • High filling accuracy
  • Simple orientation, quick changeovers, and low maintenance
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance with end-user requirements
  • Container feeding from unscrambling units, rotary or bi-flow tables, depending on the process, and layout configuration
  • Vacuum stoppering for oxygen sensitive products
  • Intermediate tank with level controller using weighing cells
  • Closure presence control and automatic rejection systems
  • Statistical or 100% IPC
  • Nitrogen purging before, after, during, and after the filling operation
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation

Filling type is chosen based on product characteristics and end user requirements.

  • Rotary piston pumps (standard)
  • Peristaltic pumps
  • Mass flow meters
  • Time-pressure filling system
  • Custom dosing systems

Cartridge Filling and Closing

cartridge filling

Automatic filling and closing machines for glass and plastic cartridges in bulk or nested, suitable for sterile applications.

Our innovative filling machines infeed cartridges to the filling area via start transport system with no glass-to-glass contact to prevent glass breakage. The plungers are positioned automatically. Cartridges move to the filling station, then are automatically transferred down the line to the capping and crimping station where cartridges are closed with an aluminum cap. The closing process is optimized for minimal particle generation.

Cartridge filling and closing lines can be integrated with our packaging lines for automatic inline transfer to nesting, tubbing, or custom packaging stations (upon request).  

Automatic inspection systems can be integrated at every station for components presence inspection, particulate matter inspection, fill-level check, and cosmetic inspection.

  • Easy cleaning for all working surfaces
  • High filling accuracy
  • Simple orientation, quick changeovers, and low maintenance
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance with end-user requirements
  • Container feeding from unscrambling units, rotary or bi-flow tables, depending on the process, and layout configuration
  • Vacuum stoppering for oxygen sensitive products
  • Intermediate tank with level controller using weighing cells
  • Closure presence control and automatic rejection systems
  • Statistical or 100% IPC
  • Nitrogen purging before, after, during, and after the filling operation
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation

Filling type is chosen based on product characteristics and end user requirements.

  • Rotary piston pumps (standard)
  • Peristaltic pumps
  • Mass flow meters
  • Time-pressure filling system
  • Custom dosing systems

Microdose Filling and Closing

The Microdose Filling and Closing machine is a compact and precise system designed for Microdosing liquid or semi-solid products into microtubes, wells, or carousels (40 µl to 400 µl). The system has been designed for use in sterile and nonsterile filling applications for the pharmaceutical, diagnostic and biotechnology sectors.

  • Carousels are placed in a vibrating bowl that orients them in the right position. A visual system detects the orientation of the carousels. A pick and place will take the carousels and position them into the line.
  • Multiple filling nozzles are used to fill the carousels or tubes. Each filling station has a load cell for feedback of the weight filled.
  • After sealing the filled carousel or tubes, they are sent to inspection stations for multiple integrity checks: cosmetic inspection, leak testing, print and label inspection.

Different closing and sealing options available dependent on the product characteristics and end-user requirements.

  • Aluminum foil
  • Tyvek
  • Polyester film

  • Dosing pumps can be easily detached from the machine base to facilitate setup and cleaning.
  • Dosing station can maintain reagents at specific temperatures for temperature-sensitive reagents.
  • Flexible design that can fill with different reagents and with different amounts in the same carousel with multiple wells.
  • The filled and sealed containers can be sent to an accumulation table, exit conveyor, or integrated inline with our packaging systems.

Bottle Filling and Closing

bottle filling

Our bottle filling and closing machines are suited for high-speed filling, plugging, and capping of both sterile and non-sterile applications such as syrup, ophthalmic solutions, and nasal sprays in either glass or plastic containers.

The bottle filling and closing lines can work as a stand-alone machine or integrated into a turnkey production line with our washing, inspection, or packaging systems.

  • Ability to accommodate multiple closing stations for different types of caps (screw caps, plungers, droppers, etc.)
  • Easy cleaning for all working surfaces
  • High filling accuracy
  • Simple orientation, quick changeovers, and low maintenance
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance with end-user requirements
  • Container feeding from unscrambling units, rotary or bi-flow tables, depending on the process, and layout configuration
  • Closure presence control and automatic rejection systems
  • Statistical or 100% IPC
  • Nitrogen purging before, after, during, and after the filling operation
  • CIP/SIP functionalities
  • Remote assistance
  • Documentation packages for complete system validation

Filling type is chosen based on product characteristics and end user requirements.

  • Rotary piston pumps
  • Peristaltic pumps
  • Mass flow meters
  • Time-pressure filling system (standard)
  • Custom dosing systems

Nested Syringes, Cartridges, and Vials

Description

Option for our filling machines to be designed to handle nested containers in aseptic conditions.

The machine receives the opened tub in the filling area. A pick and place system moves the nest to the filling station. After filling and stoppering, the nest is re-positioned into the tub.

The nested filling and sealing machines can be used as stand-alone equipment or integrated into a turnkey line with our inspection and packaging systems.

The machine can be equipped with conventional LAF or RABs.

  • De-bagging and de-lidding stations: the machine can have a module for either manual or automated de-bagging and de-lidding by robots.
  • De-nesting and re-nesting: robotic precision handling of containers for de-nesting and re-nesting operations.
  • A labeling unit can be integrated downstream.
  • Secure recipe management

Multiple Containers

multiple containers filling equipment

Our multi-container filling and closing machines are designed to be highly flexible and can process a wide range of containers such as vials, cartridges, and prefilled syringes either in bulk or nested.

The flexible filling and closing line is designed to process multiple container formats and sizes in the same line with quick and easy changeover processes. This design allows for a smaller machine footprint and increased production output.

  • Easy cleaning for all working surfaces
  • High filling accuracy
  • Simple orientation, quick changeovers, and low maintenance
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance with end-user requirements
  • Container feeding from unscrambling units, rotary or bi-flow tables, depending on the process, and layout configuration
  • Vacuum stoppering for oxygen sensitive products
  • Intermediate tank with level controller using weighing cells
  • Closure presence control and automatic rejection systems
  • Statistical or 100% IPC
  • Nitrogen purging before, after, during, and after the filling operation
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation

Filling type is chosen based on product characteristics and end user requirements.

  • Rotary piston pumps (standard)
  • Peristaltic pumps
  • Mass flow meters
  • Time-pressure filling system
  • Custom dosing systems

Bag Filling

We provide semi-automatic and fully automatic machines for filling and closing of preformed bags of various capacities and materials (PVC, PE, PP, etc.) for single chamber and multi-chamber bags.

The dosing unit is equipped with mass-flow meters that guarantee an accurate and stable filling process. Different filling devices can also be used depending on the product characteristics.

The machine can process bags of very small and very large filling outputs (SVP and LVP).

  • Easy cleaning for all working surfaces
  • High filling accuracy
  • Simple orientation, quick changeovers, and low maintenance
  • User friendly touch screen operator interface (HMI)
  • Customized layout in accordance with end-user requirements
  • Container feeding from unscrambling units, rotary or bi-flow tables, depending on the process, and layout configuration
  • Vacuum stoppering for oxygen sensitive products
  • Intermediate tank with level controller using weighing cells
  • Closure presence control and automatic rejection systems
  • Statistical or 100% IPC
  • Nitrogen purging before, after, during, and after the filling operation
  • CIP/SIP functionalities
  • Integration with conventional LAF units or RABS
  • Preparation for isolation technology
  • Remote assistance
  • Documentation packages for complete system validation