Products

Pharmaceutical Freeze Dryers

We offer standard and customized freeze dryer solutions from pilot models to large industrial scale from our partner. Together with our customers, we work closely with our research, validation, and production teams to provide the best machine layout and processes that meet all customer requirements. 

All freeze dryers are designed to meet strict FDA and cGMP requirements. 

Our advanced research plant performs pilot tests to confirm theoretical conditions of the clients’ processes before the installation of equipment. This process is done to ensure maximum results from every machine. 

  • Industrial Freeze Dryers 
  • Pilot Scale Freeze Dryers 
  • Automatic Loading and Unloading Systems (ALUS)

Fast Delivery Models:

  • 7 m2 (6 + 1 shelves) [min vapor flux 5.7 kg/h and max ice capacity 200kg] – horizontal automatic load/unload system
  • 30 m2 (18+ 1 shelves) [min vapor flux 25 kg/h and max ice capacity 900kg] – vertical automatic load/unload system

The models can be customized to meet user requirement specifications and integrate automatic loading/unloading systems.

  • Compact and easy to operate units 
  • FDA compliant design  
  • Extensive and detailed documentation
  • User friendly, tried, and tested control system 
  • Fabrication and finish quality to exceed cGMP. 
  • High performance refrigeration system  
  • Versatile solutions:
    • Pilot plant (0.5 m²)
    • Industrial production plant (60m² or greater)

Many of the our freeze dryers are manufactured for high technology applications requiring sterilization. Designs are continually improving, supported by intensive validation studies. All freeze dryers can be easily sterilized with sterilization medium (steam is still the internationally preferred medium).

  • Cleaning systems (CIP) reaching all areas 
  • Through steam sterilization (SIP) designed for easy validation

 

Technical Features of Freeze-Dryers with Stoppering Device
Model  C 3-1S C 24-4S C50-4S C 76-6S C 118-6S C 156-8S C 182-5S C 218-6S C 242-8S C 366-10s C 438-12S z
No. Shelves 1 4 4 6 6 8 5 6 8 10 12
Dimensions (cm) 30×30 62×48 62×100 62×100 98×100 98×100 126×145 126×145 126×145 126×145 126×145
Loading Surface (m²) 0.09 1.2 2.5 3.7 5.9 7.8 9.1 10.9 14.6 18.4 21.9
Distance between Shelves (mm) 120 120 120 120 120 100 100 100 100 100 100
Temp. of Shelves (°C) -50 – 70
Min Temp. of condenser (°C) -70
Condensing nominal capacity (kg) 3 24 50 74 118 156 182 218 292 368 438
No. of Trays 310x480x40 (mm) 8 16 24 36 48 60 72 96 120 144
Overall Dimensions
Width (mm) 1800 1000 1000 1000 1440 1440 1740 1740 1740 1740 1740
Depth (mm) 850 2300 3000 3500 3500 4100 4200 4200 4200 4900 4900
Height (mm) 1700 2000 2000 2000 2200 2280 1900 2020 2280 2540 2800
Electrical Control Cabinet
Width (mm) 770 770 770 1350 1350 1350 1350 1350 1350 1350 1350
Depth (mm) 550 550 550 550 550 550 550 550 550 550 550
Height (mm) 1920 1920 1920 1920 1920 1920 1920 1920 1920 1920 1920
Refrigeration Units Dimensions according to plant location
Power (kW) 5 10 18 25 30 39 45 55 69 70 80
Total Weight (Kg) 900 1600 2400 3000 3700 5200 5650 6250 6700 7350 8200
Vials (Ø 13) (mm) 530 1040 14080 21120 31680 42240 52800 63360 84480 105600 126720
Ampouls (Ø 22) (mm) 190 2480 4960 7440 11160 14880 18600 22320 29760 37200 44640
Freeze Dryers with varying features can be manufactured upon request
Freeze Dryers with Steam Sterilization (121.1°C) are built upon request
Freeze Dryers with liquid Nitrogen
Technical Features of Freeze-Dryers without Stoppering Device
Model  C 3-1 C24-4 C 50-4 C 74-6 C118-6 C 156-8 C 200-8 C 252-10 C 292-8 C 366-10 C 438-12 C 540-12 C810-15
No. Shelves 1 4 4 6 6 8 8 10 8 10 12 12 15
Dimensions (cm) 30×30 62×48 62×100 62×100 98×100 98×100 126×100 126×100 126×145 126×145 126×145 155×145 150×180
Loading Surface (m²) 0.09 1.2 2.5 3.7 5.9 7.8 10 12.6 14.6 18.4 21.9 27.0 40.5
Distance between Shelves (mm) 120 120 120 120 120 120 120 120 120 120 100 100 100
Temp. of Shelves (°C) -50 – 70
Min Temp. of condenser (°C) -70
Condensing nominal capacity (kg) 3 24 50 74 118 156 200 252 292 368 438 540 810
No. of Trays 310x480x40 (mm) 8 16 24 36 48 64 80 96 120 144 180 225*
*Trays 200x600x40 (mm)
Overall Dimensions
Width (mm) 1800 800 900 900 1300 1300 1570 1570 1570 1570 1570 1900 1900
Depth (mm) 850 2000 2600 2600 3400 3400 3400 3400 4500 4800 4800 4900 5300
Height (mm) 1700 2000 2000 2000 2000 2300 2300 2600 2300 2600 2640 2640 2700
Electrical Control Cabinet
Width (mm) 770 770 770 1350 1350 1350 1350 1350 1350 1350 1350 1350 1350
Depth (mm) 550
Height (mm) 1920
Refrigeration Units Dimensions according to plant location
Power (kW) 5 10 18 25 30 39 45 55 63 70 80 100 160
Total Weight (Kg) 850 1500 2300 2900 3500 5000 5400 5800 6400 7000 7800 9000 12000
Vials (Ø 13) (mm) 530 7040 14080 21120 31680 42240 56320 70400 84480 105600 126720 158400 243000
Ampouls (Ø 22) (mm) 190 2480 4960 7440 11160 14880 19840 24800 29760 37200 44640 55800 85500
Freeze Dryers with varying features can be manufactured upon request
Freeze Dryers with Steam Sterilization (121.1°C) are built upon request

Freeze Dryers with liquid Nitrogen

 

Technical features of Freeze-Dryers without stoppering device
Model  C 814-15 C 110-15 C1250-16 C14–018 C 1600-20 C 1800-18 C 2000-20
No. Shelves 15 17 16 18 20 18 20
Dimensions (cm) 157×175 157×186 157×250 157×250 157×250 207×250 207×250
Loading Surface (m²) 40 50 62 70 80 90 100
Distance between Shelves (mm) 80 80 80 80 80 90 100
Temp. of Shelves (°C) -50 – 70
Min Temp. of condenser (°C) -75
Condensing nominal capacity (kg) 814 1100 1250 1500 1600 1800 2000
No. of Trays ACCORDING TO CUSTOMER REQUEST
Overall Dimensions
Width (mm) ACCORDING TO PLANT LAYOUT
Depth (mm)
Height (mm)
Electrical Control Cabinet
Width (mm) ACCORDING TO PLANT LAYOUT
Depth (mm)
Height (mm)
Refrigeration Units Dimensions according to plant location
Power (kW) 270 310 360 400 440 480 520
Total Weight (Kg) 22000 28000 34000 38000 44000 49000 55000
Freeze Dryers with varying features can be manufactured upon request
Freeze Dryers with Steam Sterilization (121.1°C) are built upon request
Freeze Dryers with liquid Nitrogen
Technical features of Freeze-Dryers without stoppering device
Model  C 500-11S C 540-12S C 600-13S C 632-12S C 724-12S C 834-12S C 904-13S
No. Shelves 11 12 13 12 13 12 13
Dimensions (cm) 1.5×1.5 1.5×1.5 1.5×1.5 1.5×1.86 1.5×1.86 1.5×2.32 1.5×2.32
Loading Surface (m²) 25.0 27.0 30.0 33.4 26.2 41.7 45.2
Distance between Shelves (mm) 100
Temp. of Shelves (°C) -50 – 70
Min Temp. of condenser (°C) -75 -70
Condensing nominal capacity (kg) 500 540 600 632 724 834 904
No. of Trays ACCORDING TO CUSTOMER REQUEST
Overall Dimensions
Width (mm) 2250 2250 2250 2250 2250 2250 2250
Depth (mm) 4200 4200 4200 4800 4800 5200 5200
Height (mm) 2400 2500 2600 2500 2600 2500 2600
Electrical Control Cabinet
Width (mm) 1600 1600 2400 2400 2400 2400 2400
Depth (mm) 800
Height (mm) 2200
Refrigeration Units Dimensions according to plant location
Power (kW) 180 190 200 230 240 270 300
Total Weight (Kg) 11000 13000 15000 17000 19000 22000 24000
Vials ACCORDING TO CUSTOMER TRAY DIMENSIONS
Ampouls
Freeze Dryers with varying features can be manufactured upon request
Freeze Dryers with Steam Sterilization (121.1°C) are built upon request
Freeze Dryers with liquid Nitrogen

Custom designed solutions for loading systems of bulk product, vials, or ampoules: 

  • Loading at constant level  
  • Loading shelf by shelf or all shelves at one time 
  • Double or single door solutions 
  • Intermediate storage before and after lyophilization 
  • Protective environments during loading and unloading 
  • Loading and unloading under LAF or isolator

Our validation staff can support our customers in any step of the O.Q. (Operation Qualification) and P.Q. (Performance Qualification) of the S.I.P. validation tests.

Preliminary validation carried out at the factory in the presence of the buyer’s expert personnel